Trifluoroacetic acid → (1-Acetyl-4-{4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-1H-pyrazol-1-yl}piperidin-4-yl)acetonitrile
반응식
[C:1](O)([C:3](F)(F)F)=[O:2].[N:8]1[C:17]2[C:12](=[CH:13][C:14]([CH2:18][C:19]3[N:23]4[N:24]=[C:25]([C:28]5[CH:29]=[N:30][N:31]([C:33]6([CH2:39][C:40]#[N:41])[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]6)[CH:32]=5)[CH:26]=[N:27][C:22]4=[N:21][CH:20]=3)=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1>>[C:1]([N:36]1[CH2:37][CH2:38][C:33]([CH2:39][C:40]#[N:41])([N:31]2[CH:32]=[C:28]([C:25]3[CH:26]=[N:27][C:22]4[N:23]([C:19]([CH2:18][C:14]5[CH:13]=[C:12]6[C:17](=[CH:16][CH:15]=5)[N:8]=[CH:9][CH:10]=[CH:11]6)=[CH:20][N:21]=4)[N:24]=3)[CH:29]=[N:30]2)[CH2:34][CH2:35]1)(=[O:2])[CH3:3]참가 물질
3
실험 절차
This compound was prepared as a TFA salt starting from (4-{4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-1H-pyrazol-1-yl}piperidin-4-yl)acetonitrile using procedures analogous to those for Example 203, Step 4. LCMS: (M+H)=492.4.
출처 및 근거
- ORD 기록
- ord-1dcc6ee997d44857b7d510455545a414