Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Cyanide → 1'-(Phenylmethyl)-(1,4'-bipiperidine)-4'-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Cyanide | HCID 8929 | — |
| 반응물 | 1-Benzyl-4-piperidone | HCID 19220 | — |
| 반응물 | Piperidine, hydrochloride (1:1) | HCID 2723721 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1'-(Phenylmethyl)-(1,4'-bipiperidine)-4'-carbonitrile | HCID 2733434 | 95.4% |
반응 단계
A solution of 5.3 g of sodium cyanide in 20 ml of water is added dropwise at RT to a solution of 18.9 g of 1-benzylpiperid-4-one and 12.16 g of piperidine hydrochloride in 25 ml of MeOH and 25 ml of water and the mixture is stirred for 48 hours at RT. The precipitate formed is filtered off, washed with water and dried under vacuum to give 27 g of the expected product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06710042B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-c1e494c1679f413993b9aba28b5ed289 |
| 출처 메모 | uspto-grants-2004_03 |