Acetyl chloride → Ethyl 6-oxo-1,6-dihydropyridazine-4-carboxylate

HRID 500536노트

반응식

HRID 500536 반응식
[O:1]=[C:2]1[NH:7][N:6]=[CH:5][C:4]([C:8]([OH:10])=[O:9])=[CH:3]1.[C:11](Cl)(=O)[CH3:12]>C(O)C>[CH2:11]([O:9][C:8]([C:4]1[CH:5]=[N:6][NH:7][C:2](=[O:1])[CH:3]=1)=[O:10])[CH3:12]

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 123762656-Oxo-1,6-dihydropyridazine-4-carboxylic acid

생성물 1

HCID 12376258Ethyl 6-oxo-1,6-dihydropyridazine-4-carboxylate

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
75 °C

실험 절차

The title compound from Example 18.3 (1.0 g, 7.13 mmol) was added to a solution of ethanol (16 mL) and acetyl chloride (4 mL) and the resulting suspension was heated to 75° C. and stirred overnight. The reaction mixture was concentrated, diluted with water and extracted with dichloromethane. The organic phase was dried over sodium sulfate, filtered and concentrated to give the title compound.

후처리

  1. concentrationThe reaction mixture was concentrated
  2. additiondiluted with water
  3. extractionextracted with dichloromethane
  4. dry with materialThe organic phase was dried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-3aa33dedd9b04de8a50ea781e5e0a20b
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772235B2

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