HCID 24851818, 화합물 → HCID 24853176, 화합물

HRID 500555노트

반응식

HRID 500555 반응식
C([O:8][C:9]1[CH:14]=[C:13]([C:15]2[N:19]([CH3:20])[C:18]([O:21][CH:22]([C:24]3[CH:28]=[C:27]([C:29]4[CH:34]=[CH:33][CH:32]=[C:31]([Cl:35])[CH:30]=4)[O:26][N:25]=3)[CH3:23])=[N:17][N:16]=2)[CH:12]=[CH:11][N:10]=1)C1C=CC=CC=1>C(O)C.[Pd].ClCCl>[Cl:35][C:31]1[CH:30]=[C:29]([C:27]2[O:26][N:25]=[C:24]([CH:22]([O:21][C:18]3[N:19]([CH3:20])[C:15]([C:13]4[CH:12]=[CH:11][NH:10][C:9](=[O:8])[CH:14]=4)=[N:16][N:17]=3)[CH3:23])[CH:28]=2)[CH:34]=[CH:33][CH:32]=1

참가 물질

5

반응물 1

HCID 24851818HCID 24851818, 화합물

생성물 1

HCID 24853176HCID 24853176, 화합물수율 38%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 702Ethanol용매HCID 6344Dichloromethane용매

실험 절차

The title compound of example 35.1 (125 mg, 0.256 mmol) was stirred in ethanol (2 mL). Palladium on carbon (10%, 50 mg) was added and the reaction was stirred under hydrogen (balloon pressure) overnight. The reaction mixture was then diluted with dichloromethane and filtered to remove the palladium catalyst. The filtrate was concentrated, then chromatographed in 10% methanol in ethyl acetate to yield the desired product (38.5 mg, 38%).

후처리

  1. filtrationfiltered
  2. customto remove the palladium catalyst
  3. concentrationThe filtrate was concentrated
  4. customchromatographed in 10% methanol in ethyl acetate

출처 및 근거

ORD 기록
ord-a93f41b8699045c7999178beb229ede2
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772235B2

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