HCID 57443974, 화합물 → HCID 131728275, 화합물

반응식

COC(C1SC2C=C(CO)C=CC=2C=1)=O.[ClH:16].[CH2:17]([O:19][C:20]([C:22]1[S:26][C:25]2[CH:27]=[C:28]([CH2:31][NH2:32])[CH:29]=[CH:30][C:24]=2[CH:23]=1)=[O:21])C>>[ClH:16].[CH3:17][O:19][C:20]([C:22]1[S:26][C:25]2[CH:27]=[C:28]([CH2:31][NH2:32])[CH:29]=[CH:30][C:24]=2[CH:23]=1)=[O:21]

참가 물질

반응물 2

HCID 57443974HCID 57443974, 화합물

HCID 131728274HCID 131728274, 화합물

생성물 1

HCID 131728275HCID 131728275, 화합물

실험 절차

The title compound was prepared from 6-hydroxymethyl-benzo[b]thiophene-2-carboxylic acid methyl ester in procedures similar to those described for the preparation of 6-aminomethyl-benzo[b]thiophene-2-carboxylic acid ethyl ester, hydrochloride salt. 1H NMR (DMSO-d6, 200 MHz) δ 8.70 (brs, 2H), 8.24-8.12 (m, 2H), 8.05 (d, J=8.4 Hz, 1H), 7.63 (dd, J=8.0, 1.0 Hz, 1H), 4.20-4.14 (m, 2H), 3.88 (s, 3H). MS (EI): cal'd 222.0 (MH+), exp 222.1 (MH+).

출처 및 근거

ORD 기록: ord-a9b61993ad844b3093157c1ed771426a
출처 데이터셋: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07772238B2

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