Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,6-Dichloro-4-nitrophenol → (7-(2,6-Dichloro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)(pyrrolidin-1-yl)methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,6-Dichloro-4-nitrophenol | HCID 12066 | — |
| 반응물 | (7-Chlorothieno[3,2-b]pyridin-2-yl)(pyrrolidin-1-yl)methanone | HCID 11173165 | — |
| 반응물 | 7-(2-fluoro-4-nitrophenoxy)-N,N-dimethylthieno[3,2-b]pyridine-2-carboxamide | HCID 59424475 | — |
| 생성물 | (7-(2,6-Dichloro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)(pyrrolidin-1-yl)methanone | HCID 59424694 | 69% |
반응 단계
Starting from the compound 139 and following the procedure described above for the synthesis of compound 6 (scheme 1, example 1) but replacing 2-fluoro-4-nitrophenol with 2,6-dichloro-4-nitrophenol, title compound 140 was obtained in 69% yield. LRMS (M+1) 438.0 (100%), 439.1 (20%), 440.1 (70%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07772247B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-5e26d3efa8bf46d7bbaf674d75fe4a30 |
| 출처 메모 | uspto-grants-2010_08 |