Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Fluoro-4-nitrophenol → 4-(3-Chloro-4-nitrophenoxy)thieno[3,2-d]pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Fluoro-4-nitrophenol | HCID 9825 | — |
| 반응물 | 3-Chloro-4-nitrophenol | HCID 10283 | — |
| 반응물 | 4-Chlorothieno[3,2-d]pyrimidine | HCID 2735821 | — |
| 반응물 | 4-(2-Fluoro-4-nitrophenoxy)-N-(2-morpholinoethyl)thieno[3,2-d]pyrimidine-6-carboxamide | HCID 59424553 | — |
| 생성물 | 4-(3-Chloro-4-nitrophenoxy)thieno[3,2-d]pyrimidine | HCID 47446362 | 72% |
반응 단계
Starting from the chloride 20 (scheme 4) and following the procedure described above for the synthesis of compound 24 (scheme 4, example 22) remplacing 2-fluoro-4-nitrophenol with 3-chloro-4-nitrophenol, title compound 171 was obtained in 72% yield. LRMS (M+1) 307.7 (100%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07772247B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-5512f104ab1a4b8dbb0cca2b407814ff |
| 출처 메모 | uspto-grants-2010_08 |