6-Bromo-7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridine → 4-(6-Bromothieno[3,2-b]pyridin-7-yloxy)-3-fluorobenzenamine

HRID 500899노트

반응식

HRID 500899 반응식
[Br:1][C:2]1[C:3]([O:11][C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][C:13]=2[F:21])=[C:4]2[S:10][CH:9]=[CH:8][C:5]2=[N:6][CH:7]=1.N1C2=C(OC3C=CC(N)=CC=3F)N=CC=C2C=C1>>[Br:1][C:2]1[C:3]([O:11][C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][C:13]=2[F:21])=[C:4]2[S:10][CH:9]=[CH:8][C:5]2=[N:6][CH:7]=1

참가 물질

3

반응물 2

HCID 594244576-Bromo-7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridineHCID 594246294-(1H-Pyrrolo[2,3-c]pyridin-7-yloxy)-3-fluorobenzenamine

생성물 1

HCID 594246764-(6-Bromothieno[3,2-b]pyridin-7-yloxy)-3-fluorobenzenamine수율 92%

실험 절차

Starting from the compound 272 and following the procedure described above for the synthesis of compound 261 (scheme 59, example 218, step 3), title compound 273 was obtained in 92% yield as a light brown solid. MS (m/z): 340.0(M+H).

출처 및 근거

ORD 기록
ord-47feed4ed13a465cbf1edd5f0ea9b032
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772247B2

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