HCID 22024596, 화합물 → HCID 22024494, 화합물

HRID 500989노트

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HRID 500989 반응식
[Cl:1][C:2]1[C:3]2[N:4]([C:8]([CH:13]([OH:17])[CH2:14][CH2:15][CH3:16])=[C:9]([CH2:11][CH3:12])[N:10]=2)[CH:5]=[CH:6][N:7]=1>C(OCC)(=O)C.C(Cl)Cl.[O-2].[Mn+4].[O-2]>[Cl:1][C:2]1[C:3]2[N:4]([C:8]([C:13](=[O:17])[CH2:14][CH2:15][CH3:16])=[C:9]([CH2:11][CH3:12])[N:10]=2)[CH:5]=[CH:6][N:7]=1

참가 물질

5

반응물 1

HCID 22024596HCID 22024596, 화합물

생성물 1

HCID 22024494HCID 22024494, 화합물

시약·촉매·용매 3

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매HCID 8857Ethyl Acetate용매

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온도
60 °C

실험 절차

The resulting 1-(8-chloro-2-ethylimidazo[1,2-a]pyrazin-3-yl)-1-butanol was dissolved in ethyl acetate (4 mL) and methylene chloride (1 mL), then activated manganese (IV) oxide (3 g) was added thereto, and the mixture was heated under stirring at 60° C. for 5 hours. After being allowed to cool, the reaction mixture was filtered and washed with ethyl acetate, and then the filtrates were combined and evaporated. The resulting residue was purified by silica gel column chromatography (ethyl acetate:n-hexane=1:3) to give the title compound (226 mg) as white crystals.

후처리

  1. temperaturethe mixture was heated
  2. temperatureto cool
  3. filtrationthe reaction mixture was filtered
  4. washwashed with ethyl acetate
  5. customevaporated
  6. customThe resulting residue was purified by silica gel column chromatography (ethyl acetate:n-hexane=1:3)

출처 및 근거

ORD 기록
ord-8a75eb283eea4e508ba53ae6f570740d
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772249B2

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