Thionyl Chloride → HCID 22024658, 화합물

HRID 501008노트

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HRID 501008 반응식
[Br:1][C:2]1[C:3]([NH:8][CH:9]([CH2:12][CH3:13])[CH2:10]O)=[N:4][CH:5]=[N:6][CH:7]=1.S(Cl)(Cl)=O>C1(C)C(C)=CC=CC=1>[Br:1][C:2]1[C:3]2[N:4]([CH2:10][CH:9]([CH2:12][CH3:13])[N:8]=2)[CH:5]=[N:6][CH:7]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 22024679HCID 22024679, 화합물

생성물 1

HCID 22024658HCID 22024658, 화합물수율 98.1%

시약·촉매·용매 1

HCID 7237O-Xylene용매

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온도
100 °C

실험 절차

2-[(5-Bromo-4-pyrimidinyl)amino]-1-butanol (3.3 g) was dissolved in xylene (27 mL), then thionyl chloride (4.9 mL) was added thereto, and the mixture was heated under stirring at 100° C. for 1 day. The precipitated crystals were collected by filtration and suspended in a 1M aqueous sodium carbonate solution. This mixture was extracted with dichloromethane to give the crude title compound (3.0 g) as an orange oil. This title compound was used in the next reaction without purification.

후처리

  1. temperaturethe mixture was heated
  2. filtrationThe precipitated crystals were collected by filtration
  3. extractionThis mixture was extracted with dichloromethane

출처 및 근거

ORD 기록
ord-281fe9257f52469ab646f0b24a9f47fc
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772249B2

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