Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-(2,3-Difluorophenyl)-1-(2-methoxyethyl)-3-nitropyridin-2(1H)-one → 3-Amino-5-(2,3-difluorophenyl)-1-(2-methoxyethyl)piperidin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-(2,3-Difluorophenyl)-1-(2-methoxyethyl)-3-nitropyridin-2(1H)-one | HCID 22293173 | — |
| 촉매 | Platinum | HCID 23939 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 3-Amino-5-(2,3-difluorophenyl)-1-(2-methoxyethyl)piperidin-2-one | HCID 22293194 | — |
반응 단계
10% Platinum on carbon (320 mg) was added to a solution of 5-(2,3-difluorophenyl)-1-(2-methoxyethyl)-3-nitropyridin-2(1H)-one (300 mg, 0.967 mmol) in acetic acid (10 mL). The reaction vessel was evacuated and back-filled with nitrogen (3×), then back-filled with hydrogen (56 psi). After 65 h, the mixture was filtered and concentrated. MS 285 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07772224B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-876ecca9833d433f9543482715ac2ffa |
| 출처 메모 | uspto-grants-2010_08 |