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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Methylcyclohexane → (1S,2S)-2-methoxycarbonylcyclopropanecarboxylic acid

HRID 501276
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인쇄 미리보기

반응식

HRID 501276 반응식
[CH3:1][O:2][C:3]([C@@H:5]1[CH2:7][C@H:6]1[C:8]([OH:10])=[O:9])=[O:4].COC1C=CC2N=CC=C([C@@H](O)[C@H]3N4C[C@H](C=C)[C@@H](CC4)C3)C=2C=1.CC1CCCCC1>CC(C)=O>[CH3:1][O:2][C:3]([C@H:5]1[CH2:7][C@@H:6]1[C:8]([OH:10])=[O:9])=[O:4]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 7962MethylcyclohexaneHCID 3034034QuinineHCID 12510972rac-(1R,2R)-2-(methoxycarbonyl)cyclopropane-1-carboxylic acid

생성물 1

HCID 11708069(1S,2S)-2-methoxycarbonylcyclopropanecarboxylic acid

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Add trans-cyclopropane-1,2-dicarboxylic acid monomethyl ester, Example 3a, (19.46 g) in acetone to quinine (43.8 g) In one portion. Heat the reaction to reflux, and then add methylcyclohexane (150 mL). After crystallization (5 times) from acetone/methylcyclohexane, collect 6.2 g of the diastereomeric salt (═D:+173, c:7.3 CHCl3)

후처리

  1. temperatureHeat
  2. customthe reaction
  3. temperatureto reflux
  4. customAfter crystallization (5 times) from acetone/methylcyclohexane
  5. customcollect 6.2 g of the diastereomeric salt (═D:+173, c:7.3 CHCl3)

출처 및 근거

ORD 기록
ord-b3d4d03aaf4f430899b14e31c6577805
출처 데이터셋
uspto-grants-2010_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07772252B2

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