1-(3-Chlorophenyl)piperazine monohydrochloride → HCID 178461364, 화합물

HRID 501284

반응식

HRID 501284 반응식
[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9]([C@@H:11]2[CH2:13][C@H:12]2[CH2:14]OS(C)(=O)=O)=[O:10])[CH2:4][CH2:3]1.Cl.[Cl:21][C:22]1[CH:23]=[C:24]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH:25]=[CH:26][CH:27]=1>C(#N)C>[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9]([C@@H:11]2[CH2:13][C@H:12]2[CH2:14][N:31]2[CH2:30][CH2:29][N:28]([C:24]3[CH:25]=[CH:26][CH:27]=[C:22]([Cl:21])[CH:23]=3)[CH2:33][CH2:32]2)=[O:10])[CH2:4][CH2:3]1

참가 물질

4

반응물 2

HCID 256811-(3-Chlorophenyl)piperazine monohydrochlorideHCID 178505300HCID 178505300, 화합물

생성물 1

HCID 178461364HCID 178461364, 화합물수율 29%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Reflux a solution of methane sulfonic acid 2-(trans-4-methyl-cyclohexylcarbamoyl)-trans-cyclopropylmethyl ester (Example 11d) (30.0 mg, 0.1 mmol), 1-(3-chloro-phenyl)-piperazine hydrochloride (29.0 mg, 0.13 mmol) triethylamine (0.05 mL, 0.4 mmol) in acetonitrile (5 ml) for 15 h. Concentrate the reaction mixture under vacuum and chromatograph the residue over silica gel to obtain 11.3 mg (28%) of solid, LC/MS, m/z=390 (M+H)+.

후처리

  1. concentrationConcentrate the reaction mixture under vacuum and chromatograph the residue over silica gel

출처 및 근거

ORD 기록
ord-4ed63e670f8a4d2d89cf4e8a68715f96
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772252B2

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