8-(3-Aminopiperidin-1-yl)-7-(2-butynyl)-1-(2-cyanobenzyl)-6-oxo-6,7-dihydro-1H-purine-2-carbonitrile hydrochloride → 8-(3-Aminopiperidin-1-yl)-7-(2-butynyl)-1-(4-cyanobenzyl)-6-oxo-6,7-dihydro-1H-purine-2-carbonitrile hydrochloride
반응식
C(N1C2C(=O)[N:11]([CH2:15][C:16]3[CH:21]=[CH:20][C:19](C#N)=[CH:18][CH:17]=3)C([Cl:24])=NC=2N=C1N1CCCC(NC(=O)OC(C)(C)C)C1)C#CC.Cl.[NH2:40][CH:41]1[CH2:46][CH2:45][CH2:44][N:43]([C:47]2[N:55]([CH2:56][C:57]#[C:58][CH3:59])[C:54]3[C:53](=[O:60])[N:52]([CH2:61]C4C=CC=CC=4C#N)[C:51]([C:70]#[N:71])=[N:50][C:49]=3[N:48]=2)[CH2:42]1>>[ClH:24].[NH2:40][CH:41]1[CH2:46][CH2:45][CH2:44][N:43]([C:47]2[N:55]([CH2:56][C:57]#[C:58][CH3:59])[C:54]3[C:53](=[O:60])[N:52]([CH2:61][C:19]4[CH:20]=[CH:21][C:16]([C:15]#[N:11])=[CH:17][CH:18]=4)[C:51]([C:70]#[N:71])=[N:50][C:49]=3[N:48]=2)[CH2:42]1참가 물질
3
반응물 2
생성물 1
실험 절차
The title compound was synthesized by using t-butyl [1-[7-(2-butynyl)-2-chloro-1-(4-cyanobenzyl)-6-oxo-6,7-dihydro-1H-purin-8-yl]piperidin-3-yl]carbamate according to the method described in Examples 242 (f) and (g).