Dimethylamine → 1-Benzyl-7-dimethylamino-5-methyl-1,5-dihydroimidazo[4,5-d]pyridazin-4-one

HRID 501433노트

반응식

HRID 501433 반응식
[CH3:1][NH:2][CH3:3].[CH2:4]([N:11]1[C:15]2[C:16](Cl)=[N:17][N:18]([CH3:21])[C:19](=[O:20])[C:14]=2[N:13]=[CH:12]1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>C(O)C>[CH2:4]([N:11]1[C:15]2[C:16]([N:2]([CH3:3])[CH3:1])=[N:17][N:18]([CH3:21])[C:19](=[O:20])[C:14]=2[N:13]=[CH:12]1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 574728321-Benzyl-7-chloro-5-methyl-1,5-dihydroimidazo[4,5-d]pyridazin-4-one

생성물 1

HCID 574728341-Benzyl-7-dimethylamino-5-methyl-1,5-dihydroimidazo[4,5-d]pyridazin-4-one

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
130 °C

실험 절차

A 2 ml aqueous solution of 50% dimethylamine was added to a 2 ml ethanol solution of 0.138 g of 1-benzyl-7-chloro-5-methyl-1,5-dihydroimidazo[4,5-d]pyridazin-4-one, and the mixture was heated at 130° C. for 72 hours. The reaction solution was cooled to room temperature, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography. Thus, 0.139 g of the title compound was obtained from the fraction eluted with methanol-ethyl acetate (1:19).

후처리

  1. temperatureThe reaction solution was cooled to room temperature
  2. concentrationconcentrated under reduced pressure
  3. customThe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-683381488b4b4437a187b92da8546424
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772226B2

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