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Dimethylformamide → 1-Allyl-3-benzyl-4-chloro-1,3-dihydroimidazo[4,5-c]pyridin-2-one

HRID 501441
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HRID 501441 반응식
C(=O)([O-])[O-].[K+].[K+].[CH2:7](Br)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.CN(C)C=O.[CH2:20]([N:23]1[C:31]2[CH:30]=[CH:29][N:28]=[C:27]([Cl:32])[C:26]=2[NH:25][C:24]1=[O:33])[CH:21]=[CH2:22]>C(OCC)(=O)C.O>[CH2:20]([N:23]1[C:31]2[CH:30]=[CH:29][N:28]=[C:27]([Cl:32])[C:26]=2[N:25]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:24]1=[O:33])[CH:21]=[CH2:22]
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참가 물질

7

반응물 4

HCID 6228DimethylformamideHCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 230708521-Allyl-4-chloro-1,3-dihydroimidazo[4,5-c]pyridin-2-one

생성물 1

HCID 230705921-Allyl-3-benzyl-4-chloro-1,3-dihydroimidazo[4,5-c]pyridin-2-one수율 104.6%

시약·촉매·용매 2

HCID 962
Water
용매
HCID 8857Ethyl Acetate용매

실험 절차

0.76 g of potassium carbonate and 0.94 g of benzyl bromide were added to a 50 ml N,N-dimethylformamide solution of 1.05 g of 1-allyl-4-chloro-1,3-dihydroimidazo[4,5-c]pyridin-2-one, and the mixture was stirred at room temperature for 14 hours. 300 ml of water and 300 ml of ethyl acetate were added to the solution, and the organic layer was washed three times with 100 ml of water and then with 100 ml of a saturated sodium chloride solution. The organic layer was dried over magnesium sulfate, and concentrated under reduced pressure to give 1.57 g of the title compound.

후처리

  1. washthe organic layer was washed three times with 100 ml of water
  2. dry with materialThe organic layer was dried over magnesium sulfate
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-b173aea5a05a45b28bf6b2dd5d0453f7
출처 데이터셋
uspto-grants-2010_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07772226B2

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