Ethylmorpholine → HCID 72280670, 화합물

HRID 501489노트

반응식

HRID 501489 반응식
[C:1]1([S:11]([N:14]2[CH:18]([C:19](O)=[O:20])[CH2:17][CH:16]3[CH2:22][CH2:23][CH2:24][CH:15]23)(=[O:13])=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.ClC(OCC)=O.C(N1CCOCC1)C.C[Si]([NH:43][OH:44])(C)C>CN(C=O)C>[OH:44][NH:43][C:19]([CH:18]1[N:14]([S:11]([C:1]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH:4]=[CH:3][CH:2]=2)(=[O:13])=[O:12])[CH:15]2[CH2:24][CH2:23][CH2:22][CH:16]2[CH2:17]1)=[O:20]

참가 물질

6

반응물 4

HCID 7525EthylmorpholineHCID 10928Ethyl chloroformateHCID 21936899N-Hydroxy-1,1,1-trimethylsilanamineHCID 68461196HCID 68461196, 화합물

생성물 1

HCID 72280670HCID 72280670, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

200 mg (0.56 mmol) of 1-(naphthaline-1-sulfonyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid were dissolved in 10 ml of DMF, after which 0.61 mmol of ethyl chloroformate, 1.23 mmol of N-ethylmorpholine and 1.68 mmol of trimethylsilylhydroxylamine were added. After the mixture had been heated at 80° C. for 6 h, the solvent was removed under reduced pressure and the crude product was purified using chromatographic methods.

후처리

  1. customthe solvent was removed under reduced pressure
  2. customthe crude product was purified

출처 및 근거

ORD 기록
ord-cb3fdb36be514b8293568cd8375ce0aa
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772270B2

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