Ethylmorpholine → HCID 72412476, 화합물

HRID 501490노트

반응식

HRID 501490 반응식
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([N:14]2[CH:18]([C:19](O)=[O:20])[CH2:17][CH:16]3[CH2:22][CH2:23][CH2:24][CH:15]23)(=[O:13])=[O:12])=[CH:7][CH:6]=1)(=[O:4])=[O:3].ClC(OCC)=O.C(N1CCOCC1)C.C[Si]([NH:43][OH:44])(C)C>CN(C=O)C>[OH:44][NH:43][C:19]([CH:18]1[N:14]([S:11]([C:8]2[CH:9]=[CH:10][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[CH:6][CH:7]=2)(=[O:13])=[O:12])[CH:15]2[CH2:24][CH2:23][CH2:22][CH:16]2[CH2:17]1)=[O:20]

참가 물질

6

반응물 4

HCID 7525EthylmorpholineHCID 10928Ethyl chloroformateHCID 21936899N-Hydroxy-1,1,1-trimethylsilanamineHCID 68459175HCID 68459175, 화합물

생성물 1

HCID 72412476HCID 72412476, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

200 mg (0.55 mmol) of 1-(4-methanesulfonylbenzenesulfonyl)octahydrocyclopenta-[b]pyrrole-2-carboxylic acid were dissolved in 10 ml of DMF, after which 0.60 mmol of ethyl chloroformate, 1.22 mmol of N-ethylmorpholine and 1.67 mmol of trimethylsilylhydroxylamine were added. After the mixture had been heated at 80° C. for 4 h, the solvent was removed under reduced pressure and the crude product was purified using chromatographic methods.

후처리

  1. customthe solvent was removed under reduced pressure
  2. customthe crude product was purified

출처 및 근거

ORD 기록
ord-9fa46e8e34e542699721ebd9e27b19d7
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772270B2

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