Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(7R,7aS)-4-(7-Hydroxy-1,3-dioxotetrahydropyrrolo[1,2-c]imidazol-2-yl)-5,6,7,8-tetrahydronaphthalene-1-carbonitrile → (7R,7aS)-5-(7-Hydroxy-1,3-dioxotetrahydropyrrolo[1,2-c]imidazol-2-yl)-quinoline-8-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (7R,7aS)-4-(7-Hydroxy-1,3-dioxotetrahydropyrrolo[1,2-c]imidazol-2-yl)-5,6,7,8-tetrahydronaphthalene-1-carbonitrile | HCID 9904811 | — |
| 반응물 | N-(2,3-Dihydro-1H-inden-4-yl)acetamide | HCID 12683814 | — |
| 반응물 | 5-Nitroquinoline-8-carbonitrile | HCID 21874838 | — |
| 반응물 | 4-Isocyanato-5,6,7,8-tetrahydronaphthalene-1-carbonitrile | HCID 59754304 | — |
| 생성물 | (7R,7aS)-5-(7-Hydroxy-1,3-dioxotetrahydropyrrolo[1,2-c]imidazol-2-yl)-quinoline-8-carbonitrile | HCID 59754313 | — |
반응 단계
The title compound was synthesized from compound 12C by procedures analogous to those described in Experiment 3A and Experiment 2 (2E to 2F). 99.8% at 2.05 min (retention time) (Conditions: YMC S5 ODS (4.6×50 mm); Eluted with 0% to 100% B; 4 min gradient; (A=90% H2O-10% MeOH-0.1% H3PO4 and B=10% H2O-90% MeOH-0.1% H3PO4); Flow rate at 4 mL/min. UV detection at 220 nm). LC/MS nm/z 309 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07772267B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-361cbb36f79d4a8d8173a37d88efb6fb |
| 출처 메모 | uspto-grants-2010_08 |