Potassium Carbonate → 6-Nitroquinolin-2(1H)-one

HRID 501578노트

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HRID 501578 반응식
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([O:14]C(=O)C)[CH:8]=[CH:7]2)([O-:3])=[O:2].C([O-])([O-])=O.[K+].[K+]>CO>[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH:8]=[CH:7]2)([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 597542506-Nitro-2-acetoxyquinoline

생성물 1

HCID 8999326-Nitroquinolin-2(1H)-one수율 94.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Compound 46A (210 mg, 0.90 mmol) was dissolved in MeOH (10 mL), K2CO3 was added, and the reaction was stirred at rt for 30 min. The reaction was then concentrated under reduced pressure and subsequently purified by silica gel flash chromatography eluting with 5-10% MeOH/CH2Cl2 (gradient) to give the title compound (162 mg, 94%) as a pink solid. LC/MS m/z 191 [M+H]+.

후처리

  1. concentrationThe reaction was then concentrated under reduced pressure
  2. customsubsequently purified by silica gel flash chromatography
  3. washeluting with 5-10% MeOH/CH2Cl2 (gradient)

출처 및 근거

ORD 기록
ord-2bf9cc19f3094f8f8fc0e215360b910e
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772267B2

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