1-Bromo-2-methylpropane → 6-[(6-Chloro-pyridin-3-yl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]4-(3-ethoxy-phenyl)-1-isobutyl-1H-quinolin-2-one

HRID 50168노트

반응식

[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]([OH:35])([C:29]2[N:30]([CH3:34])[CH:31]=[N:32][CH:33]=2)[C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[NH:15][C:14](=[O:19])[CH:13]=[C:12]3[C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([O:26][CH2:27][CH3:28])[CH:21]=2)=[CH:4][CH:3]=1.Br[CH2:37][CH:38]([CH3:40])[CH3:39]>>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]([OH:35])([C:29]2[N:30]([CH3:34])[CH:31]=[N:32][CH:33]=2)[C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[N:15]([CH2:37][CH:38]([CH3:40])[CH3:39])[C:14](=[O:19])[CH:13]=[C:12]3[C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([O:26][CH2:27][CH3:28])[CH:21]=2)=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 65551-Bromo-2-methylpropane

HCID 224653976-[(6-Chloro-Pyridin-3-yl)-Hydroxy-(3-Methyl-3H-Imidazol-4-yl)-Methyl]-4-(3-Ethoxy-Phenyl)-1H-Quinolin-2-One

생성물 1

HCID 224654006-[(6-Chloro-pyridin-3-yl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]4-(3-ethoxy-phenyl)-1-isobutyl-1H-quinolin-2-one수율 42.9%

실험 절차

The same procedure described in example 8, 6-[(6-chloro-pyridin-3-yl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-ethoxy-phenyl)-1H-quinolin-2-one (50 mg, 0.103 mmol) and 1-bromo-2-methylpropane (0.022 ml, 0.206 mmol) generated the title compound as a white solid (24 mg, 40% yield).

출처 및 근거

ORD 기록: ord-3c71e74672144d9a8e9da2c41d24fa42
출처 데이터셋: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06710209B2

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