Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Hydroxybenzaldehyde → 3-Isopropoxybenzaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Hydroxybenzaldehyde | HCID 101 | — |
| 반응물 | Isopropyl iodide | HCID 6362 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | (S)-2,2,2-trifluoro-N-(6-methoxy-3-oxo-2,3-dihydro-1H-inden-1-yl)acetamide | HCID 1472787 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-Isopropoxybenzaldehyde | HCID 712914 | 85% |
반응 단계
Step AU (1). A solution of 3-hydroxybenzaldehyde (67 g, 549 mmol), 2-iodopropane (100 g, 588 mmol) and K2CO3 (130 g, 942 mmol) in 400 mL DMF was stirred for 18 h. To the above solution was added 2-iodopropane (20 g, 117 mmol) and K2CO3 (20 g, 145 mmol) and the mixture was stirred for another 24 h. The reaction mixture was poured into 300 mL water which was extracted with EtOAc (200 mL×3). The combined organic layers were washed with water (100 mL×3), dried over Na2SO4, filtered, and concentrated in vacuo to afford 77 g (85% yield) of 3-isopropoxybenzaldehyde as an oil. 1H NMR (300 MHz, CDCl3) δ 1.29-1.31 (d, 6H) 4.5-4.6 (m, 1H) 7.0-7.1 (m, 1H) 7.3-7.4 (m, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07772221B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-8571272274344ffcbf958067fbe99d83 |
| 출처 메모 | uspto-grants-2010_08 |