Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Malonic Acid → 3-Amino-3-{3-[(propan-2-yl)oxy]phenyl}propanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Malonic Acid | HCID 867 | — |
| 반응물 | Ammonium Acetate | HCID 517165 | — |
| 반응물 | 3-Isopropoxybenzaldehyde | HCID 712914 | — |
| 반응물 | 2,2,2-trifluoro-N-((1S,3R)-3-hydroxy-6-isopropoxy-2,3-dihydro-1H-inden-1-yl)acetamide | HCID 59423688 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Dichloromethane methanol | HCID 21226129 | — |
| 생성물 | 3-Amino-3-{3-[(propan-2-yl)oxy]phenyl}propanoic acid | HCID 23002627 | 62% |
반응 단계
Step AU (2). A solution of 3-isopropoxybenzaldehyde (77 g, 470 mmol), malonic acid (52 g, 496 mmol) and ammonium acetate (65 g, 844 mmol) in 1.0 L of ethanol was refluxed at 120° C. for 24 h. The solvent was evaporated in vacuo. The residue was purified using silica-gel column chromatography with (100% EtOAc, then 30% methanol/methylene chloride) to afford 65 g (62% yield) of 3-amino-3-(3-isopropoxyphenyl)propanoic acid as a white solid. LC-MS (M+H)+=224.14. 1H NMR (300 MHz, DMSO-d6) δ 1.2-1.3 (d, 6H) 2.4-2.5 (m, 2H) 4.2-4.4 (m, 1H) 4.5-4.7 (m, 1H) 6.8-6.9 (m, 1H) 6.9-7.0 (m, 2H) 7.2-7.3 (m, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07772221B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-76c2b766ae6547b9ae706f38eaa98013 |
| 출처 메모 | uspto-grants-2010_08 |