1,3-Benzenediamine, N1,N1-dimethyl-, hydrochloride (1:2) → 4-chloro-N-(3-dimethylaminophenyl)-3-(6-quinolylcarbonylamino)benzamide

HRID 502039

반응식

HRID 502039 반응식
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][C:3]=1[NH:11][C:12]([C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][CH:23]=1)[N:20]=[CH:19][CH:18]=[CH:17]2)=[O:13].Cl.Cl.[CH3:26][N:27]([CH3:35])[C:28]1[CH:29]=[C:30]([CH:32]=[CH:33][CH:34]=1)[NH2:31]>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:31][C:30]2[CH:32]=[CH:33][CH:34]=[C:28]([N:27]([CH3:35])[CH3:26])[CH:29]=2)=[O:7])=[CH:4][C:3]=1[NH:11][C:12]([C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][CH:23]=1)[N:20]=[CH:19][CH:18]=[CH:17]2)=[O:13]

참가 물질

3

반응물 2

HCID 771241,3-Benzenediamine, N1,N1-dimethyl-, hydrochloride (1:2)HCID 226361284-Chloro-3-(6-quinolylcarbonylamino)benzoyl chloride

생성물 1

HCID 98896944-chloro-N-(3-dimethylaminophenyl)-3-(6-quinolylcarbonylamino)benzamide

실험 절차

Using an analogous procedure to that described in Example 1, 4-chloro-3-(6-quinolylcarbonylamino)benzoyl chloride was reacted with 3-dimethylaminoaniline dihydrochloride to give the title compound; NMR Spectrum: (DMSOd6) 3.04 (s, 6H), 6.5 (d, 1H), 7.08-7.20(m, 3H), 7.61-7.64 (m, 1H), 7.74 (d, 1H), 7.92 (d, 1H) 8.1-8.2 (m, 2H), 7.31 (d, 1H), 8.58 (d, 1H), 8.72 (s, 1H), 9.02 (s, 1H) 10.13 (s, 1H), 10.5 (s, 1H); Mass Spectrum: Mass Spectrum: M+H+ 445 and 447.

출처 및 근거

ORD 기록
ord-16e945a363f5414dab69edaa5897ee5e
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772432B2

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