2,5-Dimethylbenzoic acid → N-[1-(4-Chloro-3-ethoxy-benzyl)piperidin-4-yl]-2,5-dimethyl-benzamide

HRID 502346

반응식

HRID 502346 반응식
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:16][CH2:17][CH3:18].[CH3:19][C:20]1[CH:28]=[CH:27][C:26]([CH3:29])=[CH:25][C:21]=1[C:22](O)=[O:23]>>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH:13][C:22](=[O:23])[C:21]3[CH:25]=[C:26]([CH3:29])[CH:27]=[CH:28][C:20]=3[CH3:19])[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:16][CH2:17][CH3:18]

참가 물질

3

반응물 2

HCID 118922,5-Dimethylbenzoic acidHCID 592103771-(4-Chloro-3-ethoxybenzyl)piperidin-4-ylamine

생성물 1

HCID 68459309N-[1-(4-Chloro-3-ethoxy-benzyl)piperidin-4-yl]-2,5-dimethyl-benzamide수율 10%

실험 절차

The title compound (4 mg, 10%) was prepared analogously to example 8 by coupling of 1-(4-chloro-3-ethoxy-benzyl)piperidin-4-ylamine with 2,5-dimethylbenzoic acid. MS: 401.4 (MH+).

출처 및 근거

ORD 기록
ord-22c95d12cd44435d9ffd2eb638b023ee
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772253B2

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