(4-Amino-3,5-diethoxy-phenyl)-methanol → 4-Amino-3,5-diethoxybenzaldehyde

HRID 502360

반응식

HRID 502360 반응식
[NH2:1][C:2]1[C:7]([O:8][CH2:9][CH3:10])=[CH:6][C:5]([CH2:11][OH:12])=[CH:4][C:3]=1[O:13][CH2:14][CH3:15]>CN(C=O)C.O=[Mn]=O>[NH2:1][C:2]1[C:3]([O:13][CH2:14][CH3:15])=[CH:4][C:5]([CH:11]=[O:12])=[CH:6][C:7]=1[O:8][CH2:9][CH3:10]

참가 물질

4

반응물 1

HCID 66912271(4-Amino-3,5-diethoxy-phenyl)-methanol

생성물 1

HCID 591282764-Amino-3,5-diethoxybenzaldehyde

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 6228Dimethylformamide용매

실험 절차

To a solution of (4-amino-3,5-diethoxy-phenyl)-methanol (0.79 g, 3.74 mmol) in DMF (20 mL) was added MnO2 (1.63 g, 18.70 mmol). The reaction mixture was stirred for 24 h at rt, filtered through Hyflo, the filtrate extracted with ethyl acetate (3×50 mL) and the combined organic phases dried over MgSO4 providing 0.69 g (88%) of the title compound. 1H NMR (300 MHz, DMSO): δ1.46 (t, J=7.0 Hz, 3H), 4.15 (q, J=7.0 Hz, 2H), 4.50 (br s, 2H), 7.04 (s, 2H), 9.70 (s, 1H).

후처리

  1. filtrationfiltered through Hyflo
  2. extractionthe filtrate extracted with ethyl acetate (3×50 mL)
  3. dry with materialthe combined organic phases dried over MgSO4 providing 0.69 g (88%) of the title compound

출처 및 근거

ORD 기록
ord-906b1ab5bd6c4313ad21a37d895959eb
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772253B2

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