4-Methylamino-3-nitrobenzenesulfonic acid-n-methyl-n-(1-methylpiperidin-4-yl)amide → HCID 18412481, 화합물

HRID 50237노트

반응식

HRID 50237 반응식
[CH3:1][N:2]([CH:17]1[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]1)[S:3]([C:6]1[CH:11]=[CH:10][C:9]([NH:12][CH3:13])=[C:8]([N+:14]([O-])=O)[CH:7]=1)(=[O:5])=[O:4].ClCCl.C(O)C>CO.[H][H].[Pd]>[CH3:1][N:2]([CH:17]1[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]1)[S:3]([C:6]1[CH:11]=[CH:10][C:9]([NH:12][CH3:13])=[C:8]([NH2:14])[CH:7]=1)(=[O:5])=[O:4]

참가 물질

6

반응물 2

HCID 184126614-Methylamino-3-nitrobenzenesulfonic acid-n-methyl-n-(1-methylpiperidin-4-yl)amideHCID 21584144Dichloromethane ethanol

생성물 1

HCID 18412481HCID 18412481, 화합물

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 178418361HCID 178418361, 화합물용매

실험 절차

1.5 g (4.4 mmol) of 4-methylamino-3-nitrobenzenesulfonic acid-N-methyl-N-(1-methylpiperidin-4-yl)amide were dissolved in 100 mL methanol and catalytically hydrogenated at room temperature and under 5 bar hydrogen pressure (10% palladium on charcoal). Then the catalyst was filtered off and the filtrate was evaporated down. The resulting oily product was further reacted without any purification. Yield: 1.4 g (100% of theory), C14H24N4O2S (312.4); Rf value: 0.33 (silica gel; dichloromethane/ethanol=4:1).

후처리

  1. filtrationThen the catalyst was filtered off
  2. customthe filtrate was evaporated down
  3. customThe resulting oily product was further reacted without any purification

출처 및 근거

ORD 기록
ord-764f1c61911a49cca01da460a75300f3
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06710055B2

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