Ethylvanillin → N-[1-(3-Ethoxy-4-hydroxy-benzyl)piperidin-4-yl]-5-methyl-nicotinamide

반응식

[CH3:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:16]=1)[C:7]([NH:9][CH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)=[O:8].[CH2:17]([O:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[OH:28])[CH:23]=O)[CH3:18]>>[CH2:17]([O:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[OH:28])[CH2:23][N:13]1[CH2:12][CH2:11][CH:10]([NH:9][C:7](=[O:8])[C:6]2[CH:16]=[C:2]([CH3:1])[CH:3]=[N:4][CH:5]=2)[CH2:15][CH2:14]1)[CH3:18]

참가 물질

반응물 2

HCID 8467Ethylvanillin

HCID 655621085-Methyl-N-(piperidin-4-yl)-nicotinamide

생성물 1

HCID 68458774N-[1-(3-Ethoxy-4-hydroxy-benzyl)piperidin-4-yl]-5-methyl-nicotinamide수율 100%

실험 절차

The title compound (37 mg, 100%) was prepared analogously to example 30 from 5-methyl-N-(piperidin-4-yl)-nicotinamide and 3-ethoxy-4-hydroxy-benzaldehyde. MS: 370.5 (MH+).

출처 및 근거

ORD 기록: ord-8b794f83f60844de909f2355ca0972ba
출처 데이터셋: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07772253B2

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