Diethyl Ether → 2-Benzofuran-3-yl-ethanol

HRID 502503노트

반응식

HRID 502503 반응식
CO[C:3](=O)[CH2:4][C:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[O:7][CH:6]=1.[Li].CC[O:18]CC>>[CH:6]1[O:7][C:8]([CH:13]([OH:18])[CH3:12])=[C:9]2[CH:10]=[CH:11][CH:3]=[CH:4][C:5]=12

참가 물질

4

반응물 3

HCID 3283Diethyl Ether2회HCID 3028194LithiumHCID 10976279Methyl Benzofuran-3-acetate

생성물 1

HCID 684582562-Benzofuran-3-yl-ethanol

실험 절차

A solution of benzofuran-3-yl-acetic acid methyl ester (4.0 g, 21 mmol) in 25 ml of ether was added dropwise at RT to a suspension of lithium alanate (1.61 g, 59.5 mmol) in 35 ml of ether, and stirring was then carried out for 30 minutes. Excess alanate was then hydrolysed with ethanol, the mixture was suction-filtered over Kieselguhr, and the solvent was removed in vacuo. The product was obtained in the form of a yellowish oil in a yield of 3.0 g (89%).

후처리

  1. filtrationhydrolysed with ethanol, the mixture was suction-filtered over Kieselguhr
  2. customthe solvent was removed in vacuo
  3. customThe product was obtained in the form of a yellowish oil in a yield of 3.0 g (89%)

출처 및 근거

ORD 기록
ord-59bad4e82581494b96c626227b667a12
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07776848B2

반응 노트

불러오는 중…