Potassium Hydroxide → 2-(1-Methylethyl)-3-quinolinol

HRID 502626노트

반응식

HRID 502626 반응식
[CH:1]([C:4]1[C:13]([O:14]S(C2C=CC(C)=CC=2)(=O)=O)=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1)([CH3:3])[CH3:2].[OH-].[K+].O1CCOCC1>O>[CH:1]([C:4]1[C:13]([OH:14])=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1)([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 14797Potassium HydroxideHCID 312751,4-DioxaneHCID 86611057Toluene-4-sulfonic acid 2-isopropyl-quinolin-3-yl ester

생성물 1

HCID 684606892-(1-Methylethyl)-3-quinolinol수율 99.8%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of toluene-4-sulfonic acid 2-isopropyl-quinolin-3-yl ester (1.31 g, 3.8 mmol), 0.64 g (11.4 mmol) of KOH in 10 mL of water, and 50 mL of p-dioxane was heated to refluxe for 1.5 hours until completion. The p-dioxane was removed under reduced pressure and the residue was diluted with water and acidified with 1N HCl to pH=6. The aqueous solution was extracted with ethyl acetate and the combined organic layers were washed with brine, dried (MgSO4) and concentrated under reduced pressure to afford quantitatively 0.71 g of 2-isopropyl-quinolin-3-ol

후처리

  1. temperaturewas heated
  2. customThe p-dioxane was removed under reduced pressure
  3. additionthe residue was diluted with water
  4. extractionThe aqueous solution was extracted with ethyl acetate
  5. washthe combined organic layers were washed with brine
  6. dry with materialdried (MgSO4)
  7. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-9b92362140dd45df8c9f8b860560080f
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07776872B2

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