1,2-Dimethoxyethane → N-isopropyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)furo[2,3-d]pyrimidin-4-amine

HRID 502638노트

반응식

HRID 502638 반응식
Br[C:2]1[O:14][C:5]2[N:6]=[CH:7][N:8]=[C:9]([NH:10][CH:11]([CH3:13])[CH3:12])[C:4]=2[C:3]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.CC1(C)C(C)(C)OB([C:29]2[CH:42]=[CH:41][C:32]([O:33][CH2:34][CH2:35][N:36]3[CH2:40][CH2:39][CH2:38][CH2:37]3)=[CH:31][CH:30]=2)O1.C(=O)([O-])[O-].[K+].[K+].COCCOC>O>[CH:11]([NH:10][C:9]1[C:4]2[C:3]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[C:2]([C:29]3[CH:30]=[CH:31][C:32]([O:33][CH2:34][CH2:35][N:36]4[CH2:37][CH2:38][CH2:39][CH2:40]4)=[CH:41][CH:42]=3)[O:14][C:5]=2[N:6]=[CH:7][N:8]=1)([CH3:13])[CH3:12]

참가 물질

6

반응물 4

HCID 80711,2-DimethoxyethaneHCID 11430Potassium CarbonateHCID 567768331-(2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethyl)pyrrolidineHCID 586033206-Bromo-n-isopropyl-5-phenylfuro[2,3-d]pyrimidin-4-amine

생성물 1

HCID 11626406N-isopropyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)furo[2,3-d]pyrimidin-4-amine

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
75 °C

실험 절차

Into a 16×100 mm vial sparged with argon was placed 6-bromo-N-isopropyl-5-phenylfuro[2,3-d]pyrimidin-4-amine (100 mg, 0.301 mmol), 1-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethyl)pyrrolidine (120 mg, 0.361 mmol), palladium tetrakistriphenylphosphine (17 mg, 0.015 mmol), potassium carbonate (125 mg, 0.903 mmol), DME (4 mL), and water (1 mL). The vial was sealed and heated to 75° C. for 24 hours.

후처리

  1. customInto a 16×100 mm vial sparged with argon
  2. customThe vial was sealed

출처 및 근거

ORD 기록
ord-50b0a70f52624f8d829dbec6fa167111
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07776867B2

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