Trifluoroacetic acid → Trifluoroacetate

HRID 502672노트

반응식

HRID 502672 반응식
C(OC(=O)[NH:7][CH2:8][CH:9]1[CH2:13][CH2:12][CH2:11][S:10]1)(C)(C)C.[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18]>C(Cl)Cl>[S:10]1[CH2:11][CH2:12][CH2:13][CH:9]1[CH2:8][NH2:7].[F:15][C:16]([F:21])([F:20])[C:17]([O-:19])=[O:18]

참가 물질

5

반응물 2

HCID 6422Trifluoroacetic acid2회HCID 68460638HCID 68460638, 화합물

생성물 2

HCID 84468Trifluoroacetate수율 83%HCID 15629560Tetrahydro-2-thiophenemethanamine

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of 2-[(N-tbutoxycarbonlylamino)methyl]-tetrahydrothiophene 222 (500 mg, 2.3 mmol) in DCM (25 mL) was treated with trifluoroacetic acid (10 mL). The mixture was stirred at rt for 1 h before the DCM and excess TFA were removed under reduced pressure. The oily residue was triturated with diethyl ether to afford 223 as its trifluoroacetate salt (440 mg, 1.9 mmol, 83%) as an off-white solid, which was used without further purification.

후처리

  1. customwere removed under reduced pressure
  2. customThe oily residue was triturated with diethyl ether

출처 및 근거

ORD 기록
ord-74f7f6cb35b34a97b55b6f19c66b4494
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07776867B2

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