3-(Trifluoromethyl)phenyl isocyanate → 1-(4-Iodo-3-methylphenyl)-3-(3-(trifluoromethyl)phenyl)urea

HRID 502698노트

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HRID 502698 반응식
[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[CH3:9].[N:10]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=1)=[C:11]=[O:12].[N-]=C=O>C1C=CC=CC=1>[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:11]([NH:10][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:20])([F:21])[F:22])[CH:14]=2)=[O:12])=[CH:4][C:3]=1[CH3:9]

참가 물질

5

반응물 3

HCID 94833-(Trifluoromethyl)phenyl isocyanateHCID 105034IsocyanateHCID 27342754-Iodo-3-methylaniline

생성물 1

HCID 684617451-(4-Iodo-3-methylphenyl)-3-(3-(trifluoromethyl)phenyl)urea

시약·촉매·용매 1

HCID 241Benzene용매

반응 조건

온도
90 °C

실험 절차

To a solution of 4-iodo-3-methylaniline (200 mg, 0.86 mmol) in benzene (5 mL) in a sealable tube was added 1-isocyanato-3-(trifluoromethyl)benzene (0.133 mL, 0.94 mL; “E” is an electrophilic group disussed in scheme 3, and here is an isocyanate). The tube was sealed and heated at 90° C. for 4 h. The mixture was allowed to cool to room temperature before filtering. The off white solid was washed with additional benzene (10 mL) and used without further purification.

후처리

  1. customThe tube was sealed
  2. temperatureto cool to room temperature
  3. filtrationbefore filtering
  4. washThe off white solid was washed with additional benzene (10 mL)
  5. customused without further purification

출처 및 근거

ORD 기록
ord-efc27e70662e4cee8cae76e17e6d8d75
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07776869B2

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