Hydrochloric Acid → 1-Methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-n-hexyloxycarbonylethyl)amide Hydrochloride

참여 물질

역할	이름	HCID	투입량
반응물	Hydrochloric Acid	HCID 313	—
반응물	Ethyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo(d)imidazole-5-carboxamido)propanoate hydrochloride	HCID 18412337	—
용매	1-Hexanol	HCID 8103	—
생성물	1-Methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-n-hexyloxycarbonylethyl)amide Hydrochloride	HCID 18412503	53%

반응 단계

0.60 g (1.1 mmol) of 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride were added to about 30 mL of n-hexanol saturated with hydrogen chloride and the mixture was stirred for 19 hours at room temperature. Then the hexanol was distilled off in vacuo, the residue was mixed with about 5 mL of 1N ammonia solution with stirring, and evaporated down once more. The crude product thus obtained was purified by column chromatography (silica gel, dichloromethane/methanol=5:1). Yield: 53% of theory, C31H37N7O3 (555.7); Rf value: 0.36 (silica gel; dichloromethane/methanol=5:1); EKA mass spectrum: (M+H)+=556.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06710055B2
출처 데이터셋	uspto-grants-2004_03
ORD ID	ord-4d1832ce30f0448394e3e90a4bfaca2e
출처 메모	uspto-grants-2004_03