Benzaldehyde → benzyl-{2-[3-(2-methoxy-ethoxy)-phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-amine

HRID 502799노트

반응식

HRID 502799 반응식
[BH4-].[CH3:2][O:3][CH2:4][CH2:5][O:6][C:7]1[CH:8]=[C:9]([C:13]2[NH:22][C:16]3=[N:17][CH:18]=[C:19]([NH2:21])[CH:20]=[C:15]3[CH:14]=2)[CH:10]=[CH:11][CH:12]=1.[CH:23](=O)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>CO>[CH2:23]([NH:21][C:19]1[CH:20]=[C:15]2[CH:14]=[C:13]([C:9]3[CH:10]=[CH:11][CH:12]=[C:7]([O:6][CH2:5][CH2:4][O:3][CH3:2])[CH:8]=3)[NH:22][C:16]2=[N:17][CH:18]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

참가 물질

5

반응물 3

HCID 240BenzaldehydeHCID 28123BorohydrideHCID 684656192-[3-(2-methoxy-ethoxy)-phenyl]-1H-pyrrolo[2,3-b]pyridin-5-ylamine

생성물 1

HCID 16061683benzyl-{2-[3-(2-methoxy-ethoxy)-phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-amine수율 7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Polymer supported borohydride (706 mg, 1.8 mmol) was added to a mixture of 2-[3-(2-methoxy-ethoxy)-phenyl]-1H-pyrrolo[2,3-b]pyridin-5-ylamine (50 mg, 0.18 mmol) and benzaldehyde (18mg, 0.18 mmol) in methanol (3 mL). The mixture was stirred for 16 hours, filtered, concentrated in vacuo and purified by preparative HPLC to afford benzyl-{2-[3-(2-methoxy-ethoxy)-phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-amine (4.4 mg, 7%)

후처리

  1. filtrationfiltered
  2. concentrationconcentrated in vacuo
  3. custompurified by preparative HPLC

출처 및 근거

ORD 기록
ord-eb5e2057c06b42b5a2f9ef0350934c31
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07776878B2

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