Dimethylformamide → 1-Bromo-2-(chloromethyl)-4-iodobenzene

HRID 502845노트

반응식

HRID 502845 반응식
S(Cl)([Cl:3])=O.[Br:5][C:6]1[CH:11]=[CH:10][C:9]([I:12])=[CH:8][C:7]=1[CH2:13]O.CN(C=O)C>ClCCl>[Br:5][C:6]1[CH:11]=[CH:10][C:9]([I:12])=[CH:8][C:7]=1[CH2:13][Cl:3]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 53424372(2-Bromo-5-iodophenyl)methanol

생성물 1

HCID 593463281-Bromo-2-(chloromethyl)-4-iodobenzene

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Thionyl chloride (13 mL) is added to a suspension of 4-bromo-3-hydroxymethyl-1-iodo-benzene (47.0 g) in dichloromethane (100 mL) containing DMF (0.1 mL). The mixture is stirred at ambient temperature for 3 h. Then, the solvent and the excess reagent is removed under reduced pressure. The residue is triturated with methanol and dried.

후처리

  1. customThen, the solvent and the excess reagent is removed under reduced pressure
  2. customThe residue is triturated with methanol
  3. customdried

출처 및 근거

ORD 기록
ord-7688fa39bab94122a6c9be36a60b16b2
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07776830B2

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