Acetic Acid → 1H-Indazole-5-carboxylic acid
반응식
[NH:1]1[C:9]2[C:4](=[CH:5]C(C#N)=[CH:7][CH:8]=2)[CH:3]=[N:2]1.[C:12]([OH:15])(=[O:14])[CH3:13].S(=O)(=O)(O)O>O>[NH:1]1[C:9]2[C:4](=[CH:5][C:13]([C:12]([OH:15])=[O:14])=[CH:7][CH:8]=2)[CH:3]=[N:2]1참가 물질
5
반응 조건
- 온도
- 110 °C
실험 절차
To 867 mg of 1H-5-indazolecarbonitrile used in Production Example I-14-a were added 8 ml of glacial acetic acid, 2.5 ml of water and 2 ml of concentrated sulfuric acid, and the mixture was stirred at 110° C. for 10 hours. After standing to cool, the mixture was added with 50 ml of water, and the resulting crystals were collected by filtration and dried in vacuo, to give 911 mg of the title compound as white crystals.
후처리
- temperatureto cool
- filtrationthe resulting crystals were collected by filtration
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-bc204de5d52c48139819620d59ac1096
- 출처 데이터셋
- uspto-grants-2010_08
- 특허 번호
- US07776890B2
반응 노트
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