1-(2,2-Diethoxyethoxy)-4-fluorobenzene → 5-Fluoro-1-benzofuran

HRID 503141노트

반응식

HRID 503141 반응식
C(O[CH:4](OCC)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)C>CCCCCC>[CH:9]1[C:10]([F:13])=[CH:11][C:12]2[CH:4]=[CH:5][O:6][C:7]=2[CH:8]=1

참가 물질

3

반응물 1

HCID 114475181-(2,2-Diethoxyethoxy)-4-fluorobenzene

생성물 1

HCID 117883225-Fluoro-1-benzofuran수율 50.3%

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

To a solution of 16.0 g of 1-(2,2-diethoxyethoxy)-4-fluorobenzene in 50 ml n-hexane was added 3.2 g of amberlyst 15 at room temperature. After the mixture was treated in a sealed tube at 200° C. for 11 hours, the amberlyst 15 was filtered off. The solvent was evaporated, and the crude product was purified and separated by silica gel column chromatography (n-hexane), to give 4.8 g of the title compound as a colorless oil.

후처리

  1. additionAfter the mixture was treated in a sealed tube at 200° C. for 11 hours
  2. filtrationthe amberlyst 15 was filtered off
  3. customThe solvent was evaporated
  4. customthe crude product was purified
  5. customseparated by silica gel column chromatography (n-hexane)

출처 및 근거

ORD 기록
ord-9ad81ba0fc00467bad532f8eb00437ac
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07776890B2

반응 노트

불러오는 중…