Boron tribromide → 2-Fluoro-4,5-dihydroxybenzaldehyde
반응식
[F:1][C:2]1[CH:9]=[C:8]([O:10]C)[C:7]([O:12]C)=[CH:6][C:3]=1[CH:4]=[O:5].B(Br)(Br)Br>ClCCl>[F:1][C:2]1[CH:9]=[C:8]([OH:10])[C:7]([OH:12])=[CH:6][C:3]=1[CH:4]=[O:5]참가 물질
4
반응 조건
- 온도
- -30 °C
실험 절차
To a stirred suspension of 2-fluoro-4,5-dimethoxy-benzaldehyde (3.00 g, 16.3 mmol) in dichloromethane (100 mL) was added BBr3 (12.2 mL, 130 mmol) dropwise at −78° C. under nitrogen atmosphere. After addition, the mixture was warmed to −30° C. and stirred at this temperature for 5 h. The reaction mixture was poured into ice water and the precipitated solid was collected by filtration and washed with dichloromethane to afford 2-fluoro-4,5-dihydroxy-benzaldehyde (8.0 g), which was used directly in the next step.
후처리
- additionAfter addition
- filtrationthe precipitated solid was collected by filtration
- washwashed with dichloromethane
출처 및 근거
- ORD 기록
- ord-22b1f1f3fc494bc489ae6eecda623320
- 출처 데이터셋
- uspto-grants-2010_08
- 특허 번호
- US07776905B2
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