참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1,4-Dichlorophthalazine | HCID 78490 | — |
| 반응물 | Decahydroisoquinoline | HCID 97812 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 1-chloro-4-(octahydroisoquinolin-2(1H)-yl)phthalazine | HCID 59427349 | — |
반응 단계
A resealable pressure bottle was charged with 1,4-dichlorophthalazine (1258 mg, 6.28 mmol), decahydroisoquinoline (588 μl, 3.95 mmol), potassium carbonate (546 mg, 3.95 mmol) and DMSO (20 mL, 0.2 M). Reaction was stirred at 80° C. for 16 h, then cooled to RT and diluted with 5 mL of DMSO. The solution was purified by Gilson HPLC (10% to 90% CH3CN/H2O/0.1% TFA) to afford 1-chloro-4-(octahydroisoquinolin-2(1H)-yl)phthalazine. MS [M+H]=302.1. Calcd for C17H20ClN3: 301.8.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07776857B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_08 |
|---|
| ORD ID | ord-1784cd7983a2447cb36bf11ac820341b |
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| 출처 메모 | uspto-grants-2010_08 |
|---|
