6-Methoxy-2-naphthaleneboronic acid → 2-(7-Methoxy-2-naphthyl)-5-[(2-phenylbutanoyl)amino]benzamide

HRID 503696노트

반응식

HRID 503696 반응식
I[C:2]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:22])[CH:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:14][CH3:15])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[CH3:23][O:24][C:25]1[CH:26]=[C:27]2[C:32](=[CH:33][CH:34]=1)[CH:31]=[C:30](B(O)O)[CH:29]=[CH:28]2>>[CH3:23][O:24][C:25]1[CH:26]=[C:27]2[C:32]([CH:31]=[CH:30][C:29]([C:2]3[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:22])[CH:13]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[CH2:14][CH3:15])=[CH:7][C:3]=3[C:4]([NH2:6])=[O:5])=[CH:28]2)=[CH:33][CH:34]=1

참가 물질

3

반응물 2

HCID 46416926-Methoxy-2-naphthaleneboronic acidHCID 594284852-Iodo-5-[(2-phenylbutanoyl)amino]benzamide

생성물 1

HCID 116765052-(7-Methoxy-2-naphthyl)-5-[(2-phenylbutanoyl)amino]benzamide

실험 절차

50 mg (0.12 mmol) of the compound from Example 5A are reacted with 37 mg (0.18 mmol) of 6-methoxynaphthalene-2-boronic acid in analogy to the synthesis of Example 1. 27 mg (44% of theory) of product are obtained.

후처리

  1. custom27 mg (44% of theory) of product are obtained

출처 및 근거

ORD 기록
ord-65dc58b03b4c40268318dbe3929ee46e
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07776922B2

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