Methylamine → 7-chloro-N-methyl-6-phenylimidazo[1,2-a]pyrimidin-5-amine

HRID 503732노트

반응식

HRID 503732 반응식
Cl[C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[N:5]=[C:4]([Cl:11])[C:3]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[CH3:18][NH2:19]>CO>[Cl:11][C:4]1[C:3]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:2]([NH:19][CH3:18])[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[N:5]=1

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 862136335,7-Dichloro-6-phenylimidazo[1,2-a]pyrimidine

생성물 1

HCID 866306607-chloro-N-methyl-6-phenylimidazo[1,2-a]pyrimidin-5-amine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

850 mg 5,7-dichloro-6-phenylimidazo[1,2-a]pyrimidine (prepared as described for example 1) is dissolved in 18 ml of a 8M Solution of MeNH2 in methanol and stirred at room temperature for 1.5 h. The product precipitates upon dilution with water and cooling to 0° C. The solid material is collected by filtration and washed twice with water to yield the desired material.

후처리

  1. customThe product precipitates upon dilution with water
  2. temperaturecooling to 0° C
  3. filtrationThe solid material is collected by filtration
  4. washwashed twice with water

출처 및 근거

ORD 기록
ord-184a8489cdac4a6eae8641de2d7db552
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07776864B2

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