Nitric Acid → Citrulline Dinitrate

HRID 504077

반응식

HRID 504077 반응식
[N+:1]([O-:4])([OH:3])=[O:2].[NH2:5][C@H:6]([C:14]([OH:16])=[O:15])[CH2:7][CH2:8][CH2:9][NH:10][C:11]([NH2:13])=[O:12].[N+:17]([O-:20])([OH:19])=[O:18].[NH2:21][C@H:22]([C:30]([OH:32])=[O:31])[CH2:23][CH2:24][CH2:25][NH:26][C:27]([NH2:29])=[O:28]>O>[N+:1]([O-:4])([OH:3])=[O:2].[N+:17]([O-:20])([OH:19])=[O:18].[NH2:5][C@H:6]([C:14]([OH:16])=[O:15])[CH2:7][CH2:8][CH2:9][NH:10][C:11]([NH2:13])=[O:12].[N+:1]([O-:4])([OH:3])=[O:2].[N+:1]([O-:4])([OH:3])=[O:2].[N+:1]([O-:4])([OH:3])=[O:2].[NH2:21][C@H:22]([C:30]([OH:32])=[O:31])[CH2:23][CH2:24][CH2:25][NH:26][C:27]([NH2:29])=[O:28]

참가 물질

6

반응물 3

HCID 944Nitric AcidHCID 9750CitrullineHCID 86628843Citrulline Nitrate

생성물 2

HCID 86628841Citrulline DinitrateHCID 86628842Citrulline Trinitrate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Applicants have cost-effectively synthesized Citrulline Nitrate by combining nitric acid and Citrulline, mixing with water, and leaving to crystallize. Further nitratization can take place, yielding Citrulline Dinitrate or Citrulline Trinitrate. An alternative implementation may comprise using Nitrous Acid (HNO2) instead of Nitric Acid (HNO3), thus yielding Citrulline Nitrite. Citrulline Nitrite has the same effects as Citrulline Nitrate, the only difference being that it requires one less step to yield Nitric Oxide (NO—). Mixed salts may also be used, such as in the non-limiting example of Citrulline Nitrate-Orotate.

후처리

  1. customleaving
  2. customto crystallize

출처 및 근거

ORD 기록
ord-b8b9eed9b40442cfad0dcc931ccda334
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07777074B2

연결된 노트

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