Borane → HCID 66662523, 화합물
반응식
B.[C:2]1([C@H:8]2[CH2:12][CH2:11][NH:10][C@@H:9]2[C:13](O)=[O:14])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>O1CCCC1>[C:2]1([C@H:8]2[CH2:12][CH2:11][NH:10][C@@H:9]2[CH2:13][OH:14])[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1참가 물질
4
실험 절차
Borane in tetrahydrofuran (1.0 M, 1.0 mL) was added to (2S,3R)-3-phenylpyrrolidine-2-carboxylic acid (30.0 mg, 0.000157 mol) in tetrahydrofuran (1.0 mL, 0.012 mol) at rt. After stirring for 1 h the solvent was evaporated under reduced pressure and the residue was azeotroped with methanol (3×2 mL) to afford the desired product, which was directly used in next step reaction without further purification.
후처리
- customwas evaporated under reduced pressure
- customthe residue was azeotroped with methanol (3×2 mL)
출처 및 근거
- ORD 기록
- ord-356abdc803294caf8fd2a99b66c8cda9
- 출처 데이터셋
- uspto-grants-2010_08
- 특허 번호
- US07776874B2
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