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4'-[2-(1-tert-butoxycarbonyl-piperidin-4-yloxy)-5-chloro-phenyl]-6-chloro-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione → 6-chloro-4'-[5-chloro-2-(4-piperidinyloxy)-phenyl]-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

HRID 504468
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인쇄 미리보기

반응식

HRID 504468 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=2[CH:22]2[CH2:27][C:26](=[O:28])[NH:25][CH:24]([C:29]3[CH:34]=[C:33]([F:35])[CH:32]=[CH:31][C:30]=3[CH3:36])[C:23]32[C:44]2[C:39](=[CH:40][C:41]([Cl:45])=[CH:42][CH:43]=2)[NH:38][C:37]3=[O:46])[CH2:10][CH2:9]1)=O)(C)(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[Cl:45][C:41]1[CH:40]=[C:39]2[NH:38][C:37](=[O:46])[C:23]3([CH:22]([C:16]4[CH:17]=[C:18]([Cl:21])[CH:19]=[CH:20][C:15]=4[O:14][CH:11]4[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]4)[CH2:27][C:26](=[O:28])[NH:25][CH:24]3[C:29]3[CH:34]=[C:33]([F:35])[CH:32]=[CH:31][C:30]=3[CH3:36])[C:44]2=[CH:43][CH:42]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 1

HCID 749285074'-[2-(1-tert-butoxycarbonyl-piperidin-4-yloxy)-5-chloro-phenyl]-6-chloro-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

생성물 1

HCID 749287696-chloro-4'-[5-chloro-2-(4-piperidinyloxy)-phenyl]-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione수율 105.5%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 6422Trifluoroacetic acid
용매

실험 절차

A solution of racemic (2′S,3S,4′R)-4′-[2-(1-tert-butoxycarbonyl-piperidin-4-yloxy)-5-chloro-phenyl]-6-chloro-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione (0.7 g, 1 mmol) in TFA (10 mL) was stirred at r.t. for 0.5 h. The solution was diluted with DCM, washed with 1N Na2CO3 aq. (50 mL) and brine (50 mL), dried over anhydrous Na2SO4, concentrated to give title compound as a yellow solid (Yield: 0.6 g).

후처리

  1. washwashed with 1N Na2CO3 aq. (50 mL) and brine (50 mL)
  2. dry with materialdried over anhydrous Na2SO4
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-6b55f4d974e64fd19ebddca312d0b6fc
출처 데이터셋
uspto-grants-2010_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07776875B2

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