Dichloromethane → 5-Chloro-2-(4-methoxy-phenoxy)-benzaldehyde

HRID 504522

반응식

HRID 504522 반응식
C([O-])([O-])=O.[Na+].[Na+].[CH3:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1.[Cl:16][C:17]1[CH:18]=[CH:19][C:20](F)=[C:21]([CH:24]=1)[CH:22]=[O:23].C(Cl)Cl>CN(C)C(=O)C.O>[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([O:15][C:12]2[CH:13]=[CH:14][C:9]([O:8][CH3:7])=[CH:10][CH:11]=2)=[C:21]([CH:24]=1)[CH:22]=[O:23]

참가 물질

7

반응물 4

HCID 6344DichloromethaneHCID 90154-MethoxyphenolHCID 10340Sodium CarbonateHCID 27735865-Chloro-2-fluorobenzaldehyde

생성물 1

HCID 577501175-Chloro-2-(4-methoxy-phenoxy)-benzaldehyde수율 60.9%

시약·촉매·용매 2

HCID 962Water용매HCID 31374Dimethylacetamide용매

실험 절차

At the room temperature, anhydrous Na2CO3 (16 g, 0.15 mol) was added into a mixture of 4-methoxy-phenol (14.8 g, 0.12 mol) and 5-chloro-2-fluoro-benzaldehyde (16 g, 0.10 mol) in N,N-Dimethylacetamide (100 mL). After the mixture was refluxed for 3 h, it was cooled to room temperature. Then DCM and water were added. The organic phase was separated, washed with aqueous NaOH (1 N) and brine, dried over anhydrous Na2SO4 and concentrated to give the title compound (16 g).

후처리

  1. temperatureAfter the mixture was refluxed for 3 h
  2. customThe organic phase was separated
  3. washwashed with aqueous NaOH (1 N) and brine
  4. dry with materialdried over anhydrous Na2SO4
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-7a7dd403969f4058a2dd6a2d4c8f1bf7
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07776875B2

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