Dimethylformamide → 2-(2-(2-(3-Nitrophenoxy)ethoxy)ethoxy)ethanol

HRID 5048

반응식

HRID 5048 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([OH:10])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].CN(C)C=O.C(=O)([O-])[O-].[K+].[K+].Cl[CH2:23][CH2:24][O:25][CH2:26][CH2:27][O:28][CH2:29][CH2:30][OH:31]>O.C(OCC)(=O)C>[N+:1]([C:4]1[CH:5]=[C:6]([CH:7]=[CH:8][CH:9]=1)[O:10][CH2:23][CH2:24][O:25][CH2:26][CH2:27][O:28][CH2:29][CH2:30][OH:31])([O-:3])=[O:2]

참가 물질

7

반응물 4

HCID 6228DimethylformamideHCID 111373-NitrophenolHCID 11430Potassium CarbonateHCID 788712-(2-(2-Chloroethoxy)ethoxy)ethanol

생성물 1

HCID 197977512-(2-(2-(3-Nitrophenoxy)ethoxy)ethoxy)ethanol

시약·촉매·용매 2

HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

While stirring a mixture of 27.8 g of m-nitrophenol, 120 ml of N,N-dimethylformamide, and 25 g of potassium carbonate at 80° C., 37 g of 2-(2-(2-chloroethoxy)ethoxy)-ethanol was added dropwise to the mixture. After stirring the mixture for one hour at 80° C., 200 ml of ethyl acetate and 200 ml of water were added to the reaction mixture and the ethyl acetate layer was extracted. The ethyl acetate layer was washed with 200 ml of water and concentrated to remove ethyl acetate to provide 2-(2-(2-(3-nitrophenoxy)ethoxy)ethoxy)ethanol (1-A).

후처리

  1. stirringAfter stirring the mixture for one hour at 80° C.
  2. extractionthe ethyl acetate layer was extracted
  3. washThe ethyl acetate layer was washed with 200 ml of water
  4. concentrationconcentrated
  5. customto remove ethyl acetate

출처 및 근거

ORD 기록
ord-90395268b2774bc9b14694b06a459c4d
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05243004

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