Water → 2,6-Difluoro-4-formylbenzonitrile
반응식
[F:1][C:2]1[CH:9]=[C:8]([CH:10](S(C)=O)SC)[CH:7]=[C:6]([F:16])[C:3]=1[C:4]#[N:5].S(=O)(=O)(O)[OH:18].O>C1COCC1>[F:1][C:2]1[CH:9]=[C:8]([CH:10]=[O:18])[CH:7]=[C:6]([F:16])[C:3]=1[C:4]#[N:5]참가 물질
5
실험 절차
2,6-Difluoro-4[(methylsulfinyl)(methylthio)methyl]benzonitrile (2.17 g, 8.32 mmol; see step (i) above) was dissolved in 90 mL of THF and 3.5 mL of concentrated sulfuric acid was added. The mixture was left at room temperature for 3 days and subsequently poured into 450 mL of water. Extraction three times with EtOAc followed and the combined ethereal phase was washed twice with aqueous sodium bicarbonate and with brine, dried (Na2SO4) and evaporated.
후처리
- extractionExtraction three times with EtOAc
- washthe combined ethereal phase was washed twice with aqueous sodium bicarbonate and with brine
- dry with materialdried (Na2SO4)
- customevaporated
출처 및 근거
- ORD 기록
- ord-bb035ad1785a4d0bbc57a768d2cc98f3
- 출처 데이터셋
- uspto-grants-2010_08
- 특허 번호
- US07781424B2
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