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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 505041생성일: 2026년 10월 27일

2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid → 2-{4-[2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoylamino]-imidazol-1-yl}-2-methyl-propionic acid methyl ester

https://huagongshe.com/reaction/505041

반응식

참여 물질

역할이름HCID투입량
반응물2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acidHCID 21112802—
반응물methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoateHCID 67164903—
생성물2-{4-[2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoylamino]-imidazol-1-yl}-2-methyl-propionic acid methyl esterHCID 11705041—

반응 단계

2-Methyl-2-(4-nitro-imidazol-1-yl)-propionic acid methyl ester was reduced and coupled with 2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid to afford the title compound; MS 449.3 m/z (M+1).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07781435B2
출처 데이터셋uspto-grants-2010_08
ORD IDord-f0a91a09417249f38e23402aa6407ade
출처 메모uspto-grants-2010_08