2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid → HCID 16113790, 화합물

HRID 505046

반응식

HRID 505046 반응식
[CH3:1][C:2]1([CH2:6][N:7]2[CH:11]=[C:10]([N+:12]([O-])=O)[N:9]=[CH:8]2)[CH2:5][O:4][CH2:3]1.[F:15][C:16]1[CH:17]=[C:18]2[C:23](=[C:24]([F:26])[CH:25]=1)[CH2:22][CH:21]([NH:27][CH:28]([CH2:32][CH2:33][CH3:34])[C:29](O)=[O:30])[CH2:20][CH2:19]2>>[CH3:1][C:2]1([CH2:6][N:7]2[CH:11]=[C:10]([NH:12][C:29](=[O:30])[C@@H:28]([NH:27][CH:21]3[CH2:20][CH2:19][C:18]4[C:23](=[C:24]([F:26])[CH:25]=[C:16]([F:15])[CH:17]=4)[CH2:22]3)[CH2:32][CH2:33][CH3:34])[N:9]=[CH:8]2)[CH2:5][O:4][CH2:3]1

참가 물질

3

반응물 2

HCID 211128022-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acidHCID 684649611-(3-Methyl-oxetan-3-ylmethyl)-4-nitro-1H-imidazole

생성물 1

HCID 16113790HCID 16113790, 화합물

실험 절차

1-(3-Methyl-oxetan-3-ylmethyl)-4-nitro-1H-imidazole was reduced and then coupled with 2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid (U.S. Ser. No. 11/078,898 filed Mar. 11, 2005) to afford the title compound: MS 433.3 m/z (M+1).

출처 및 근거

ORD 기록
ord-521a63e8764f41b497387d8ac046c5df
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07781435B2

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